23andMe, the leading consumer genetics company, has accumulated a wealth of genotypic and phenotypic information from participants committed to improving human health through advances in genomics. Our Therapeutics team uses this data to discover and develop novel medicines to treat important diseases. The team currently has research programs across several therapeutic areas, including oncology, skin, respiratory and cardiovascular disease.
We are seeking an outstanding Associate Scientist or Senior Associate Scientist who will contribute to the generation, discovery and characterization of antibodies across our Therapeutics portfolio.
Handle aspects of a hybridoma workflow including performing fusions, clone picking and hybridoma antibody screening
Develop and establish novel methods to improve the current antibody discovery workflows
Antibody characterization including affinity and specificity determination, epitope binning and antibody sequencing
Collaborate with therapeutic leads to plan the strategy for antibody discovery
Interpret, record and present complex biological data
Communicate and collaborate with other colleagues effectively
What you’ll bring
B.S. (+ min of 5 years’ research experience in industry or academia) or Master’s (+ min of 3 years’ research experience in industry or academia) in molecular biology, cell biology or related discipline
Strong technical expertise in molecular biology including DNA and RNA purification, diverse PCR methods (RT-PCR, RACE-PCR), Illumina Miseq library preparation, cloning
Adept in the characterization of protein-protein interaction using a variety of methods such as ELISA, FACS, Bio-Layer Interferometry (Octet) and/or surface plasmon resonance technology (Biacore)
Cell biology expertise including mammalian cell culture, transfection and running functional cell-based assays
Excellent communication skills with an ability to work both independently and in a team environment
Critical thinking with high degree of innovative and analytical skills
Experience using hybridoma technology for antibody discovery including immunization, hybridoma fusion, clone picking and screening
Experience in applying single B-cell antibody technologies to antibody discovery ( e.g. single cell FACS sorting, microfluidics)
Note: Job title will be commensurate with experience and academic credentials.